To null route a website, you'll need access to the DNS editor. There you'll change the A record to point to: 127.0.0.1

To null route an IP you'll normally use the shell command (if the IP to block was 65.21.34.4) it would be: 

route add 65.21.34.4 gw 127.0.0.1 lo

Essentially directing the IP or website DNS to 127.0.0.1 will null route the IP.

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